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Usually ships in 1 business days | | | | | | For everyone whose life has been touched by cancer, One Renegade Cell tells the story of the search for the ultimate causes of this dreaded disease. "One Renegade Cell…offers a breathtaking picture, both wonderful and frightening, of the fantastic intricacy of aberrant cellular functioning." -New York Times "Part primer, part history and part meditation. [One Renegade Cell] succeeds on all counts." -Wall Street Journal One of the leading cancer researchers in the world, Robert A. Weinberg is perfectly suited to describe the search for cancer's origins from the early days of this century to the present. Presuming little knowledge of biology, he tells how a cancer-causing virus was first discovered in 1909, how the correlation was made between chemical carcinogens and cancer, and how oncogenes (the genes that can turn a cell malignant) work. He explains clearly how malignant cells send messages to one another and also block the messages of normal cells. Finally, Weinberg predicts that cancer prevention may depend on our ability to understand the mysterious chemical clock that regulates our cells' most basic functions. One Renegade Cell offers a concise, accessible route into the complex and often daunting world of cancer and cancer research. | | | |
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| | Product Details | | Author: | Robert A. Weinberg | | Paperback: | 176 pages | | Publisher: | Basic Books | | Publication Date: | October 08, 1999 | | Language: | English | | ISBN: | 0465072763 | | Package Length: | 7.8 inches | | Package Width: | 4.96 inches | | Package Height: | 0.71 inches | | Package Weight: | 0.49 pounds | | Average Customer Rating: |  based on 16 reviews |
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Excellent book informative and easy to read Jun 05, 2010
This book was recommended to me by a colleague. We worked in monoclonal antibody manufacturing and development, so I knew a thing or two about treatment of cancer, but I knew nothing about the disease itself. It's an easy read (I read a lot of this book on the bike at the gym), it's not boring at all, and it's written clearly enough so that people with no biology knowledge at all can understand it, but that it's still very interesting and informative to people that already have a science or engineering background. I would also highly recommend reading Robert Weinberg's paper in Cell from 2000 titled The Hallmarks of Cancer. It's a great supplement.
Must read May 24, 2007
This is an amzaing manuscript. By leading the reader through the key discoveries in modern molecular oncology , Weinberg is able to elucidate the hallmarks of carginogenesis in simple, yet comprehensive ways.
This is a must read for any doctoral student. However, Weinberg simple and entertaining language will be enjoyed by anybody who has an interest in the pathways that lead to cancer.
2 of 2 found the following review helpful:
History of cancer theories for the layperson Apr 17, 2007
Here's a book that I would recommend to those people interested in learning a bit about the beginnings of cancer. In One Renegade Cell, Robert Weinberg has written an informative narrative on the history of cancer and molecular biology research, focusing on the theories and evidence behind the early days of this field: the 1970's and 80's.
Weinberg's focus is on what he knows best: the mechanisms that promote and regulate the proliferation of normal and malignant cells. And for that, his explanations are the best out there. These explanations take up the first half of the book, corresponds to the early events in the development of a tumor, and makes up a coherent story. For example, he covers oncogenes, tumor suppressors, apoptosis, and to a lesser extent DNA repair, in relatively easy-to-follow language.
In the second half of the book, Weinberg refers to other aspects of cancer progression, more reflective of the later stages of cancer - angiogenesis, immune evasion and metastasis. He essentially provides the highlight reel for these aspects of cancer, and I felt that the transitions to such topics could have used some work. But that's okay in my opinion, because Weinberg comes right out and says it on the cover - this book is specifically about *the beginning* of cancer, first and foremost.
Weinberg also avoids using overwhelmingly long lists of references that are typical of more scientific writing, as well as skipping over the many highly-technical details that are involved in actually conducting such research, making it more accessible to non-experts. Indeed, he defines every term in a way that probably only requires a minimal background in biology to understand.
6 of 6 found the following review helpful:
Excelent entry to cancer biology Apr 10, 2004
There are very few books out that give the reader an overview modern cancer biology. This short book gives a clear picture of a complex and current subject. It uses historical perspective on scientific discovery to enliven the reading. It's well organized and readable without background in biology, but with enough depth to interest biologists in other fields. I also reccomend Robert Weinberg's "Genes and the Biology of Cancer", written with Harold Varmus, which covers the same material in a little more depth.
2 of 5 found the following review helpful:
Valuable information! Feb 12, 2004
Extremely informative, written in interesting form like a scientific novel, a systematic mini-survey of the molecular biology of cancer. Takes you through 30 years of discovery, explaining how false expectations were replaced by the discovery in laboratories of right pathways. Among the useful pieces of information you'll pick up: cancer cells are not destroyed by chemo and radiation, only some DNA damage occurs. Unless the p53 gene is little enough damaged, then the tumor is not stopped, and Weinberg explains why. He fully describes the 6 mutations that are required, over time, to produce a metastasizing tumor. My wish: that Weinberg would next write a book about cancer treatments.I end with an aside for those who are in love with the red herring called "holism", and imagine that "reductionism" is dead and of little or no use in the elucidation of complexity. The entire field of genetic and cancer discoveries, all of microbiology, is nothing but plain ol' reductionism applied to very long molecules, molecules so long and often disordered in shape that new techniques of chemical analysis had to be invented (like PCR). This book and any standard text on molecular biology provides full evidence for the truth of my assertion.
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